Article
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.
Nature genetics - 1 Oct 2009
Martinez Anne-Marie, Schuettengruber Bernd, Sakr Samy, Janic Ana, Gonzalez Cayetano, Cavalli Giacomo
Abstract excerpt
Polycomb Group (PcG) proteins silence critical developmental genes and modulate cell proliferation. Using the Drosophila melanogaster eye as a model system, we show that cells with mutations in the gene locus (ph) that encodes the PcG protein Polyhomeotic (PH) overproliferate and lose both the ability to differentiate and their normal polarity. They invade the neighboring tissues and, when combined with an...
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