Article
Linkage disequilibrium score regression identifies genetic correlations between hepatocellular carcinoma and clinically relevant traits.
International journal of cancer - 1 Mar 2026
Han Younghun, Shaw Vikram R, Byun Jinyoung, Thrift Aaron P, Zhu Catherine, Li Donghui, Hatia Rikita I, Kelley Robin Kate, Cleary Sean P, Lok Anna S, Bracci Paige M, Permuth Jennifer B, Bucur Roxana, Knox Jennifer, Yuan Jian-Min, Singal Amit G, Jalal Prasun K, Ghobrial R Mark, Kono Yuko, Shah Dimpy P, Nguyen Mindie H, Parikh Neehar D, Kim Richard, Wu Hui-Chen, El-Serag Hashem, Chang Ping, Chun Yun Shin, Gu Jian, Huff Chad, Rashid Asif, Hwang Lu-Yu, Klein Alison P, Khaderi Saira A, Kaseb Ahmed O, McGlynn Kathrine A, Roberts Lewis R, Hassan Manal M, Amos Christopher I
Abstract excerpt
Hepatocellular carcinoma (HCC) mortality is increasing globally, partly due to the growing prevalence of nonviral liver diseases. Genome-wide association studies (GWAS) have identified genetic variants associated with HCC development. Leveraging GWAS summary statistics and linkage disequilibrium score regression (LDSR), we investigated disease co-development with hepatitis C virus-negative (HCV-negative) HCC to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.