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Article

Association Between Allostatic Load, Genetic Susceptibility, and Liver Cancer Incidence: A Large-Scale Prospective Cohort Study.

International journal of cancer - 1 Nov 2026

Li Danling, Zhou Zhongming, Liang Ganbo, Zeng Dongyu, Zhou Zhuoer, Li Xinyan, Qiu Tianchun, Zhang Yanjie, Lin Jingchao, Chen Yexi, Li Zhiyang

Abstract excerpt

Allostatic load (AL) reflects the cumulative physiological burden of chronic stress throughout life, potentially influencing cancer onset and prognosis. However, its association with primary liver cancer (PLC) risk and potential interaction with genetic susceptibility remains unclear. To investigate this, we analyzed 374,632 UK Biobank participants. AL was evaluated using a composite score of 13 cardiovascular,...

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Topics

Humans
Liver Neoplasms
Allostasis
Genetic Predisposition to Disease
Female
Prospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Male

Genetic Risk Score

Incidence

Risk Factors

Aged

United Kingdom

UK Biobank

Proportional Hazards Models

Source

Open in PubMed Open full text

Identifiers

PMID: 42466609
DOI: 10.1002/ijc.70583
PMCID: PMC13547981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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