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Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development

11 Jun 2025

Abstract excerpt

Background & Aims: The genetic underpinnings of hepatocellular carcinoma (HCC) remain largely unknown. Thus, we aimed to identify new genetic risk loci for HCC. Methods: We performed a genome-wide association study (GWAS) meta-analysis of 11 cohorts with validation in two independent cohorts. The identified variants were tested for effects on other hepatobiliary endpoints, and on incident HCC stratified by...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40823170
DOI: 10.1016/j.jhepr.2025.101485

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