Polygenic risk scores for neuropsychiatric, inflammatory, and cardio-metabolic traits highlight possible genetic overlap with suicide attempt and treatment-emergent suicidal ideation.

doi:10.1002/ajmg.b.32891

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Article

Polygenic risk scores for neuropsychiatric, inflammatory, and cardio-metabolic traits highlight possible genetic overlap with suicide attempt and treatment-emergent suicidal ideation.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2022

Fanelli Giuseppe, Sokolowski Marcus, Wasserman Danuta, Kasper Siegfried, Zohar Joseph, Souery Daniel, Montgomery Stuart, Albani Diego, Forloni Gianluigi, Ferentinos Panagiotis, Rujescu Dan, Mendlewicz Julien, De Ronchi Diana, Serretti Alessandro, Fabbri Chiara

Abstract excerpt

Suicide is the second cause of death among youths. Genetics may contribute to suicidal phenotypes and their co-occurrence in other neuropsychiatric and medical conditions. Our study aimed to investigate the association of polygenic risk scores (PRSs) for 24 neuropsychiatric, inflammatory, and cardio-metabolic traits/diseases with suicide attempt (SA) or treatment-worsening/emergent suicidal ideation (TWESI). PRSs...

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PMID: 35191176
DOI: 10.1002/ajmg.b.32891
PMCID: PMC9305542

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