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Article

Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.

Psychological medicine - 1 Apr 2018

Edwards A C, Docherty A R, Moscati A, Bigdeli T B, Peterson R E, Webb B T, Bacanu S-A, Hettema J M, Flint J, Kendler K S

Abstract excerpt

BACKGROUND: Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities. METHOD: The relationship...

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PMID: 28969721
DOI: 10.1017/S0033291717002148
PMCID: PMC5843532

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