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Article

The association of class II HLA alleles with tuberculosis-associated immune reconstitution inflammatory syndrome.

PLoS pathogens - 1 Sept 2025

Choshi Phuti, Pedretti Sarah, Chimbetete Tafadzwa, Gangula Rama, Shey Muki, Stek Cari, Lai Rachel P J, Wilkinson Robert, Meintjes Graeme, Phillips Elizabeth, Peter Jonny

Abstract excerpt

Genetic associations within the human leukocyte antigen (HLA) gene complex and linked genes in TB-IRIS outcomes remains population specific and not well understood. Here, we conducted a study including well characterised HIV-TB coinfected patients with (n = 86) and without (n = 124) TB-IRIS from the randomized, double-blind, prophylactic prednisone trial (PredART study) with HLA, ERAP and KIR genotyping data. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40972103
DOI: 10.1371/journal.ppat.1013497
PMCID: PMC12510654

Genes

CD4

Provenance

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