Article
Human leukocyte antigen associations with protection against tuberculosis infection and disease in human immunodeficiency virus-1 infected individuals, despite household tuberculosis exposure and immune suppression.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2021
Seedat Faheem, James Ian, Loubser Shayne, Waja Ziyaad, Mallal Simon A, Hoffmann Christopher, Tiemessen Caroline T, Chaisson Richard E, Martinson Neil A
Abstract excerpt
BACKGROUND: To determine the association of human leukocyte antigen (HLA) alleles as correlates of risk for and protection against tuberculin skin test (TST) positivity and active TB disease amongst HIV-infected adults. METHODS: Genomic DNA was extracted from 754 HIV-infected adults whole-blood. HLA-A, -B, -C and -DRB1 loci were genotyped by next generation sequencing methods. HLA alleles were analysed by the...
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