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Article

Expression of specific HLA class II alleles is associated with an increased risk for active tuberculosis and a distinct gene expression profile.

HLA - 1 Feb 2023

Chihab Leila Y, Kuan Rebecca, Phillips Elizabeth J, Mallal Simon A, Rozot Virginie, Davis Mark M, Scriba Thomas J, Sette Alessandro, Peters Bjoern, Lindestam Arlehamn Cecilia S

Abstract excerpt

Several HLA allelic variants have been associated with protection from or susceptibility to infectious and autoimmune diseases. Here, we examined whether specific HLA alleles would be associated with different Mycobacterium tuberculosis (Mtb) infection outcomes. The HLA alleles present at the -A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci were determined in a cohort of 636 individuals with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36373948
DOI: 10.1111/tan.14880
PMCID: PMC10027422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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