HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.

doi:10.1038/ng.3498

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Article

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry.

Nature genetics - 1 Mar 2016

Sveinbjornsson Gardar, Gudbjartsson Daniel F, Halldorsson Bjarni V, Kristinsson Karl G, Gottfredsson Magnus, Barrett Jeffrey C, Gudmundsson Larus J, Blondal Kai, Gylfason Arnaldur, Gudjonsson Sigurjon Axel, Helgadottir Hafdis T, Jonasdottir Adalbjorg, Jonasdottir Aslaug, Karason Ari, Kardum Ljiljana Bulat, Knežević Jelena, Kristjansson Helgi, Kristjansson Mar, Love Arthur, Luo Yang, Magnusson Olafur T, Sulem Patrick, Kong Augustine, Masson Gisli, Thorsteinsdottir Unnur, Dembic Zlatko, Nejentsev Sergey, Blondal Thorsteinn, Jonsdottir Ingileif, Stefansson Kari

Abstract excerpt

Mycobacterium tuberculosis infections cause 9 million new tuberculosis cases and 1.5 million deaths annually. To identify variants conferring risk of tuberculosis, we tested 28.3 million variants identified through whole-genome sequencing of 2,636 Icelanders for association with tuberculosis (8,162 cases and 277,643 controls), pulmonary tuberculosis (PTB) and M. tuberculosis infection. We found association of...

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PMID: 26829749
DOI: 10.1038/ng.3498
PMCID: PMC5081101

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