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Phenotypic profile of <i>Mycobacterium tuberculosis</i> -specific CD4 T cell responses in HIV-positive patients who develop Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

2022-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of co-treatment for TB and HIV-1. We characterized Mtb-specific CD4 T cell phenotype and transcription factor profile associated with the development of TB-IRIS. <h4>Methods</h4> We examined the role of CD4 T-cell transcription factors in a murine model of mycobacterial...

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Literature Corpus work: ba18a435-2c13-50c3-82de-3e5c6dbce7b7
DOI: 10.1101/2022.07.20.500909

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