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Article

A real-world data analysis of the impact of clonal hematopoiesis of indeterminate potential on therapeutic efficacy and adverse events of immune checkpoint inhibitors.

Cancer - 1 Jun 2026

Fujita Takamasa, Ishibashi Naoya, Aoyama Satoru, Kobayashi Yumi, Kamatani Takashi, Kinugasa Yusuke, Ikeda Sadakatsu

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) has been implicated in systemic inflammation. Although immune checkpoint inhibitors (ICIs) have transformed cancer care, their response rates remain modest, and some patients experience severe immune-related adverse events (irAEs). This study investigated whether CHIP affects ICI treatment efficacy and safety in patients with advanced solid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42216432
DOI: 10.1002/cncr.70398

Genes

TET2
ASXL1
DNMT3A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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