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Article

DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1.

Nucleic acids research - 20 Jun 2018

Wang Xuecong, Srivastava Yogesh, Jankowski Aleksander, Malik Vikas, Wei Yuanjie, Del Rosario Ricardo Ch, Cojocaru Vlad, Prabhakar Shyam, Jauch Ralf

Abstract excerpt

FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed 'DIV' for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperativity. Alternative structural models are consistent with either an indirect DNA-mediated cooperativity or a direct...

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Source

Open in PubMed Open full text

Identifiers

PMID: 29669022
DOI: 10.1093/nar/gky259
PMCID: PMC6009666

Genes

FOXA1
MAPT
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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