Article
Multimodal characterization of the responsiveness of eight hepatitis D virus genotype isolates to interferon-alpha treatment.
Journal of virology - 23 Oct 2025
Ding Yibo, Li Qiudi, Sha Yunlu, Si Ruilin, Feng Chengqian, Liu Mei, Feng Zhanghao, Ding Xutong, Li Ying, Fu Huiyuan, Liang Shiquan, Yao Qili, Zhang Zhenfeng, Li Feng, Urban Stephan, Guo Hongbo, Wang Wenshi
Abstract excerpt
Chronic hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis. Although humans produce 12 subtypes of interferon-alpha (IFN-α), IFN-α2a has been the only commonly used treatment against HDV. Previously, we characterized eight HDV genotype isolates with varying replication kinetics. Herein, we systematically investigated the antiviral efficacy of IFN-α2a and other IFN-α subtypes...
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