Article

Hepatitis D virus infection of stem cell-derived hepatocytes triggers an IFN- and NFκB-based innate immune response unable to clear infection

2022-08-13

Abstract excerpt

<h4>ABSTRACT</h4> Human pluripotent stem cell-derived hepatocyte-like cells (HLCs) are a valuable model to investigate host-pathogen interactions of hepatitis viruses in a mature and authentic environment. Here, we investigated the susceptibility of HLCs to the Hepatitis D Virus (HDV), a virus that in co-infection with HBV is responsible for the most severe form of viral hepatitis. Cells undergoing hepatic differ...

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Literature Corpus work: 425f801c-2349-5334-9908-a0eed88b67d2
DOI: 10.1101/2022.08.11.502443

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