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Article

Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread

27 May 2022

Abstract excerpt

Background & aims Besides HBV-dependent de novo infection, cell division-mediated spread contributes to HDV persistence and dampens the effect of antivirals that abrogate de novo infection. Nonetheless, the combination of these antivirals with interferons (IFNs) showed strong synergism in recent clinical trials, implying a complementary mode-of-action of IFNs. Therefore, we investigated the effect of IFN response...

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PMID: 35636579
DOI: 10.1016/j.jhep.2022.05.023

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