Article
Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype.
Hepatology (Baltimore, Md.) - 1 Apr 2018
Shen Fang, Li Yaming, Wang Yang, Sozzi Vitina, Revill Peter A, Liu Jiangxia, Gao Lu, Yang Guang, Lu Mengji, Sutter Kathrin, Dittmer Ulf, Chen Jieliang, Yuan Zhenghong
Abstract excerpt
Interferon-α (IFN-α) is used to treat chronic hepatitis B virus (HBV) infection, but only 20%-40% of patients respond well. Clinical observations have suggested that HBV genotype is associated with the response to IFN therapy; however, its role in viral responsiveness to IFN in HBV-infected hepatocytes remains unclear. Here, we produced infectious virions of HBV genotypes A to D to infect three well-recognized...
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