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Article

A Subset of Serous Tubal Intraepithelial Carcinoma (STIC)-Like Lesions and Concurrent High-Grade Endometrial Carcinoma Are Genomically Related Entities.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2025

da Silva Edaise M, Da Cruz Paula Arnaud, Dessources Kimberly, Gordhandas Sushmita, Selenica Pier, Abu-Rustum Nadeem R, Weigelt Britta, Murali Rajmohan

Abstract excerpt

In patients with high-grade endometrial carcinoma (HG-EC), concurrent isolated serous tubal intraepithelial carcinoma (STIC) or STIC-like lesions (STIC-LLs) in the fallopian tube(s) may be found. We sought to determine whether concurrently diagnosed HG-ECs and STIC-LLs are genetically related. Six HG-ECs, including serous carcinomas (n = 4) and carcinosarcomas with serous epithelial component (n = 2), with...

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Source

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Identifiers

PMID: 40946744
DOI: 10.1016/j.modpat.2025.100890
PMCID: PMC12646022

Genes

TP53
WT1
ERBB2
NF2
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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