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Article

Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Sept 2019

Meserve Emily E, Strickland Kyle C, Miron Alexander, Soong Thing R, Campbell Frank, Howitt Brooke E, Crum Christopher P

Abstract excerpt

Serous tubal intraepithelial carcinoma (STIC) is found in 10% to 60% of cases of tuboovarian high-grade serous carcinoma (HGSC) and is presumed to be the site of origin, linking many HGSCs to the fallopian tube. Bilateral STIC is present in ∼20% of cases. Because clonal Tp53 mutations are a defining feature of HGSC, including their associated STICs, we analyzed 4 cases of bilateral serous tubal intraepithelial...

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Identifiers

PMID: 29901519
DOI: 10.1097/PGP.0000000000000534

Genes

STIL

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Evidence of a Monoclonal Origin for Bilateral Serous Tubal Intraepithelial Neoplasia.PMID 29901519Read ↗

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