Article
The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS.
Cell reports - 24 Sept 2024
Bansod Sapana, Dodhiawala Paarth B, Geng Yutong, Bulle Ashenafi, Liu Peng, Li Lin, Townsend Reid, Grierson Patrick M, Held Jason M, Adhikari Hema, Lim Kian-Huat
Abstract excerpt
Loss-of-function mutations in the C terminus of TPL2 kinase promote oncogenesis by impeding its proteasomal degradation, leading to sustained protein expression. However, the degradation mechanism for TPL2 has remained elusive. Through proximity-dependent biotin identification (BioID), we uncovered tripartite motif-containing 4 (TRIM4) as the E3 ligase that binds and degrades TPL2 by polyubiquitination of lysines...
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