Article
A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia.
Nature cancer - 1 Jan 2025
Xu Jason, Chen Changya, Sussman Jonathan H, Yoshimura Satoshi, Vincent Tiffaney, Pölönen Petri, Hu Jianzhong, Bandyopadhyay Shovik, Elghawy Omar, Yu Wenbao, Tumulty Joseph, Chen Chia-Hui, Li Elizabeth Y, Diorio Caroline, Shraim Rawan, Newman Haley, Uppuluri Lahari, Li Alexander, Chen Gregory M, Wu David W, Ding Yang-Yang, Xu Jessica A, Karanfilovski Damjan, Lim Tristan, Hsu Miles, Thadi Anusha, Ahn Kyung Jin, Wu Chi-Yun, Peng Jacqueline, Sun Yusha, Wang Alice, Mehta Rushabh, Frank David, Meyer Lauren, Loh Mignon L, Raetz Elizabeth A, Chen Zhiguo, Wood Brent L, Devidas Meenakshi, Dunsmore Kimberly P, Winter Stuart S, Chang Ti-Cheng, Wu Gang, Pounds Stanley B, Zhang Nancy R, Carroll William, Hunger Stephen P, Bernt Kathrin, Yang Jun J, Mullighan Charles G, Tan Kai, Teachey David T
Abstract excerpt
Refractoriness to initial chemotherapy and relapse after remission are the main obstacles to curing T cell acute lymphoblastic leukemia (T-ALL). While tumor heterogeneity has been implicated in treatment failure, the cellular and genetic factors contributing to resistance and relapse remain unknown. Here we linked tumor subpopulations with clinical outcome, created an atlas of healthy pediatric hematopoiesis and...
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