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Article

In silico engineering of Trichoderma harzianum acetylesterase for enhanced thermal stability and efficiency.

Journal of biomolecular structure & dynamics - 1 May 2026

Abolhasanzadeh Parizi Ali, Lagzian Milad

Abstract excerpt

Acetylesterase, produced by Trichoderma harzianum, plays a crucial role in deacetylating hemicellulose during pulp production. Thermostable variants of this enzyme, although rare, can significantly enhance industrial efficiency by retaining activity at high temperatures. This research aims to design a thermostable variant of acetylesterase from T. harzianum IOC-3844 (EC 3.1.1.6) using computational methods. A 3D...

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Enzyme Stability
Hydrogen Bonding
Hypocreales
Molecular Dynamics Simulation
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Engineering

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PMID: 40924440
DOI: 10.1080/07391102.2025.2553348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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