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Article

High-risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation.

Haematologica - 1 Apr 2016

Morishima Satoko, Kashiwase Koichi, Matsuo Keitaro, Azuma Fumihiro, Yabe Toshio, Sato-Otsubo Aiko, Ogawa Seishi, Shiina Takashi, Satake Masahiro, Saji Hiroh, Kato Shunichi, Kodera Yoshihisa, Sasazuki Takehiko, Morishima Yasuo

Abstract excerpt

HLA molecules play an important role for immunoreactivity in allogeneic hematopoietic stem cell transplantation. To elucidate the effect of specific HLA alleles on acute graft-versus-host disease, we conducted a retrospective analysis using 6967 Japanese patients transplanted with T-cell-replete marrow from an unrelated donor. Using unbiased searches of patient and donor HLA alleles, patient and/or donor...

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Identifiers

PMID: 26768690
DOI: 10.3324/haematol.2015.136903
PMCID: PMC5004392

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