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Association between human leukocyte antigen and immunosuppressive treatment outcomes in Chinese patients with aplastic anemia

30 Jan 2023

Abstract excerpt

Background: Activated cytotoxic T cells (CTLs) recognize the auto-antigens presented on hematopoietic stem/progenitor cells (HSPCs) through class I human leukocyte antigen (HLA) molecules and play an important role in the immune pathogenesis of aplastic anemia (AA). Previous reports demonstrated that HLA was related to the disease susceptibility and response to immunosuppressive therapy (IST) in AA patients....

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Identifiers

PMID: 36793734
DOI: 10.3389/fimmu.2023.1056381

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