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Article

GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study.

Diabetes care - 1 Jul 2025

Harrall Kylie K, Glueck Deborah H, Lange Leslie A, Litkowski Elizabeth M, Vanderlinden Lauren A, Konigsberg Iain R, Cree Melanie G, Perng Wei, Dabelea Dana

Abstract excerpt

OBJECTIVE: Exposure to maternal gestational diabetes mellitus (GDM) is associated with childhood BMI. Among youth, we explored whether three different glucagon-like peptide 1 receptor gene (GLP-1R) polymorphisms modified the associations between 1) GDM and BMI trajectories and 2) GDM and markers of glucose-insulin homeostasis. RESEARCH DESIGN AND METHODS: For 464 participants from the Exploring Perinatal Outcomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40443355
DOI: 10.2337/dc25-0194
PMCID: PMC12178627

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