Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study.

doi:10.1111/jdi.14115

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Article

Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study.

Journal of diabetes investigation - 1 Mar 2024

Gao Yuan, Zhou Min, Xu Xuan, Ma Jun Yang, Qin Man Fen

Abstract excerpt

OBJECTIVE: In this study, we employed a Mendelian randomization (MR) approach to investigate the independent causal associations of six body composition traits with gestational diabetes mellitus (GDM). METHODS: Genome-wide significant levels (P < 10 × 5-8 ) of single nucleotide polymorphisms associated with body water mass, total protein, whole body fat-free mass, weight, whole body fat mass, and body fat...

Topics

Humans
Female
Pregnancy
Diabetes, Gestational
Mendelian Randomization Analysis
Body Composition
Phenotype
Polymorphism, Single Nucleotide

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Identifiers

PMID: 38013660
DOI: 10.1111/jdi.14115
PMCID: PMC10906022

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