Article
Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study.
European journal of human genetics : EJHG - 1 May 2022
He Chang, Zhang Miaoran, Li Jiuling, Wang Yiqing, Chen Lanlan, Qi Baiyu, Wen Jianping, Yang Jianli, Lin Sitong, Liu Dianyuan, Dong Ying, Wang Liying, Wang Qing, Chen Peng
Abstract excerpt
Obesity is thought to significantly impact the quality of life. In this study, we sought to evaluate the health consequences of obesity on the risk of a broad spectrum of human diseases. The causal effects of exposing to obesity on health outcomes were inferred using Mendelian randomization (MR) analyses using a fixed effects inverse-variance weighted model. The instrumental variables were SNPs associated with...
Topics
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Obesity
- Phenotype
- Polymorphism, Single Nucleotide
- Quality of Life