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Article

Mutation informatics: SARS-CoV-2 receptor-binding domain of the spike protein.

Drug discovery today - 1 Oct 2022

Verma Saroj, Patil Vaishali M, Gupta Manish K

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes mutations at a high rate and with frequent genetic reassortment (antigenic drift/shift), leading to variability in targets. The receptor-binding domain (RBD) of the spike (S) protein has a major role in the binding of SARS-CoV-2 with human angiotensin-converting enzyme 2 (ACE2). Mutations at the RBD influence the binding interaction at the...

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Amino Acids
Angiotensin-Converting Enzyme 2
COVID-19
Mutation
Peptidyl-Dipeptidase A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 35787481
DOI: 10.1016/j.drudis.2022.06.012
PMCID: PMC9250815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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