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Article

Deep mutational scanning of recent SARS-CoV-2 variants highlights changing amino acid preferences within epistatic hotspot residues.

PLoS pathogens - 1 Jun 2026

Taylor Ashley L, Starr Tyler N

Abstract excerpt

Deep mutational scans across receptor-binding domains (RBDs) of diverging SARS-CoV-2 variants reveal ongoing changes to the effects of mutations, a phenomenon known as epistasis. Careful accounting for these altered mutational effects is important in viral surveillance and forecasting, and more broadly, for understanding the impacts of epistasis on real-world viral evolutionary trajectories. Using a yeast-display...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42330076
DOI: 10.1371/journal.ppat.1014074
PMCID: PMC13309016

Genes

ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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