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The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation

3 Sept 2025

Abstract excerpt

Aging is a major risk factor for neurodegenerative diseases associated with protein aggregation, including Huntington's disease and amyotrophic lateral sclerosis (ALS). Although these diseases involve different aggregation-prone proteins, their common late onset suggests a link to converging changes resulting from aging. In this study, we found that age-associated hyperactivation of EPS8/RAC signaling in...

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PMID: 40903652
DOI: 10.1038/s43587-025-00943-w

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