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Article

Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Feb 2012

Harrington Adam J, Yacoubian Talene A, Slone Sunny R, Caldwell Kim A, Caldwell Guy A

Abstract excerpt

Disruption of the lysosomal system has emerged as a key cellular pathway in the neurotoxicity of α-synuclein (α-syn) and the progression of Parkinson's disease (PD). A large-scale RNA interference (RNAi) screen using Caenorhabditis elegans identified VPS-41, a multidomain protein involved in lysosomal protein trafficking, as a modifier of α-syn accumulation and dopaminergic neuron degeneration (Hamamichi et al.,...

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Source

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Identifiers

PMID: 22323726
DOI: 10.1523/JNEUROSCI.2606-11.2012
PMCID: PMC6621695

Genes

VPS41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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