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Article

Proportional modulation of proliferation and motility under 2D compressive stress depends on mesenchymal phenotype.

The European physical journal. E, Soft matter - 3 Sept 2025

Ben Meriem Zacchari, Meksassi Moetassem Billah, Denais Céline, Guillermet-Guibert Julie, Delarue Morgan

Abstract excerpt

Tumor development is accompanied by strong physico-chemical modifications. Among them, compressive stress can emerge in both the epithelial and stromal compartments. Using a simple two-dimensional compression assay which consisted in placing an agarose weight on top of adherent cells, we studied the impact of compressive stress on cell proliferation and motility in different pancreatic cancer cell lines. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40900254
DOI: 10.1140/epje/s10189-025-00516-0

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