Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures.

Neuro-oncology - 1 Jan 2026

Leelatian Nalin, Singh Charu, Bouffard Richard, Sundaram Ranjini K, Diggins Kirsten E, Sullivan William, Paradkar Sateja, Omay Zeynep Erson, Mobley Bret C, Gueble Susan E, Vasquez Juan C, Bindra Ranjit S

Abstract excerpt

BACKGROUND: Therapies for diffuse glioma induce DNA damage response (DDR), and strategies to exploit DDR defects are active areas of investigation. While global DNA methylation profiling effectively classifies gliomas into subtypes, the epigenetic and gene expression patterns of DDR genes, and their contribution to tumor classification and outcomes, have yet to be fully elucidated. Thus, dissecting the DDR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Neoplastic

Share to Glioma

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 40887772
DOI: 10.1093/neuonc/noaf199
PMCID: PMC12962623

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures.PMID 40887772Read ↗

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.Semantic proximity Read ↗

Genomic Profiling of lower-grade gliomas subtype with distinct molecular and clinicopathologic characteristics via altered DNA-damage repair featuresSemantic proximity Read ↗

DNA methylation signatures for 2016 WHO classification subtypes of diffuse gliomasSemantic proximity Read ↗

Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.Semantic proximity Read ↗

DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and developmentSemantic proximity Read ↗

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and spaceSemantic proximity Read ↗

Unveiling MMR deficiency in pediatric and AYA high-grade gliomas: insights from multiomic profiling.Semantic proximity Read ↗

DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomasSemantic proximity Read ↗

Molecular subclassification of diffuse gliomas: Seeing order in the chaosSemantic proximity Read ↗

Novel epigenetic signature of DNA damage response genes for prognostication and immunophenotype of non-G-CIMP glioblastomasSemantic proximity Read ↗

Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis.Semantic proximity Read ↗

A Custom DNA-Based NGS Panel for the Molecular Characterization of Patients With Diffuse Gliomas: Diagnostic and Therapeutic ApplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.