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Computational Modeling of Chromoanagenesis- or Chromothripsis-Induced SNPs in Antiapoptotic Genes: Their Impact on Protein Structure and Function.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2025

Shityakov Sergey, Nosonovsky Michael, Kravtsov Viacheslav, Skorb Ekaterina V

Abstract excerpt

Accurate detection of chromoanagenesis- or chromothripsis-induced single-nucleotide polymorphisms (SNPs) in antiapoptotic genes is crucial for understanding their impact on protein structure and function during cancer progression. To address this issue, we developed a computational model using the BCL2 gene to investigate the effects of chromothripsis-induced SNPs on the structure and function of antiapoptotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40884669
DOI: 10.1007/978-1-0716-4750-9_35

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BCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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