Article
Functional Implications of the spectrum of BCL2 mutations in Lymphoma.
Mutation research. Reviews in mutation research - 1 Jan 2000
Singh Khushboo, Briggs James M
Abstract excerpt
Mutations in the translocated BCL2 gene are often detected in diffuse large B-cell lymphomas (DLBCLs), indicating both their significance and pervasiveness. Large series genome sequencing of more than 200 DLBCLs has identified frequent BCL2 mutations clustered in the exons coding for the BH4 domain and the folded loop domain (FLD) of the protein. However, BCL2 mutations are mostly contemplated to represent...
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