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Article

In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein-based drugs against cancer.

Journal of cellular biochemistry - 1 Dec 2022

Fareed Muhammad Mazhar, Dutta Kunal, Dandekar Thomas, Tarabonda Herman, Skorb Ekaterina V, Shityakov Sergey

Abstract excerpt

BCL2 apoptosis regulator gene encodes Bcl-2 pro-survival protein, which plays an important role to evade apoptosis in various cancers. Moreover, single nucleotide polymorphisms (SNPs) in the BCL2 gene can be nonsynonymous (nsSNPs), which might affect the protein stability and probably its function. Therefore, we implement cutting-edge computational techniques based on the Spherical Polar Fourier and Monte-Carlo...

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PMID: 36146908
DOI: 10.1002/jcb.30330

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