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Breaking Boundaries in Cancer Therapy: Harnessing Chromothripsisinduced Mutations for Targeted Bcl-2 Protein Destabilization.

Current drug discovery technologies - 1 Jan 2026

Shityakov Sergey, Nosonovsky Michael, Skorb Ekaterina V, Kravtsov Viacheslav

Abstract excerpt

Chromothripsis, a phenomenon of massive genomic rearrangements, introduces extensive mutations in critical genes, affecting cell survival and apoptosis. Among these genes, the BCL-2 (Bcell lymphoma 2) gene, which plays a crucial antiapoptotic role in cancer cells, is often subjected to significant alterations. Here, we present a computational pipeline to model and analyze the structural and functional impacts of...

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PMID: 40457970
DOI: 10.2174/0115701638381646250523115445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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