Article
Molecular dissection of CRC primary tumors and their matched liver metastases reveals critical role of immune microenvironment, EMT and angiogenesis in cancer metastasis.
Scientific reports - 1 Jul 2020
Liu Jiangang, Cho Yong Beom, Hong Hye Kyung, Wu Song, Ebert Philip J, Bray Steven M, Wong Swee Seong, Ting Jason C, Calley John N, Whittington Catherine F, Bhagwat Shripad V, Reinhard Christoph, Wild Robert, Nam Do-Hyun, Aggarwal Amit, Lee Woo Yong, Peng Sheng-Bin
Abstract excerpt
Metastasis is the primary cause of cancer mortality. The primary tumors of colorectal cancer (CRC) often metastasize to the liver. In this study, we have collected 122 samples from 45 CRC patients. Among them, 32 patients have primary tumors, adjacent normal tissues, and matched liver metastases. Thirteen patients have primary tumors without distant metastasis and matched normal tissues. Characterization of these...
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