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Article

Genomics correlates of brain metastasis and progression in colorectal cancer.

Neuro-oncology - 1 Dec 2025

Gui Chengcheng, Walch Henry S, Mueller Kirin D, Boe Lillian A, Skakodub Anna, Miao Emily, Khatri Ishaani, Kumar Rahul, Padilla Mazzeo Michel, Shen Junchao, Cooper Claire, Parker Mitchell, Hsu Audree, Patel Roshal R, Ilica A Turan, Stember Joseph N, Eichholz Jordan E, Bou Nassif Rabih, Yu Kenny K H, Wilcox Jessica A, Manca Paolo, Yu Yao, Yamada Yoshiya, Imber Brandon S, Maron Steven B, Foote Michael B, Chatila Walid K, Yaeger Rona, Schultz Nikolaus, Pike Luke R G

Abstract excerpt

BACKGROUND: Brain metastasis (BM) in colorectal cancer (CRC) is a rare event that undermines longevity and neurocognitive function. However, the molecular basis of BM in CRC is poorly understood. We analyzed next-generation sequencing (NGS) from patients with CRC to identify genomic features associated with BM and intracranial progression (IP). METHODS: Patients with CRC who had NGS between 2014 and 2024 were...

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Identifiers

PMID: 40891323
DOI: 10.1093/neuonc/noaf198
PMCID: PMC12916729

Genes

SMAD4
BRAF
KRAS
MYC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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