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Article

Phenotypic Changes in a Monocyte Cluster with High Interleukin-1 Beta Expression during Long-Term Anti-CD20 Therapy.

Annals of neurology - 1 Dec 2025

Waede Mie, Kingo Christina, Damsbo Karina, Joergensen Maiken Uhrbrand, Oubounyt Mhaned, Gjerstorff Morten, Thomassen Mads, Baumbach Jan, Moeller Jesper B, Elkjaer Maria L, Illes Zsolt

Abstract excerpt

OBJECTIVE: We aimed to investigate disease-related and anti-CD20 therapy-related changes in peripheral blood mononuclear cells (PBMCs) from multiple sclerosis (MS) patients compared to healthy controls (HC) using multi-omics single-cell analysis. METHODS: Targeted single-cell sequencing of transcriptomes and epitopes was performed on PBMCs isolated from 64 blood samples collected from MS patients at baseline and...

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Share to Antigens, CD20
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40879186
DOI: 10.1002/ana.78004
PMCID: PMC12682941

Genes

CCL3
CCL4
CXCL8
CXCR4
IL1B
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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