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Article

Single-cell analysis of CD14+CD16+ monocytes identifies a subpopulation with an enhanced migratory and inflammatory phenotype.

Frontiers in immunology - 1 Jan 2025

Ruiz Vanessa Y, Calderon Tina M, Leon-Rivera Rosiris, Chilunda Vanessa, Zhang Jinghang, Berman Joan W

Abstract excerpt

Monocytes in the central nervous system (CNS) play a pivotal role in surveillance and homeostasis, and can exacerbate pathogenic processes during injury, infection, or inflammation. CD14+CD16+ monocytes exhibit diverse functions and contribute to neuroinflammatory diseases, including HIV-associated neurocognitive impairment (HIV-NCI). Analysis of human CD14+CD16+ monocytes matured in vitro by single-cell RNA...

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Source

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Identifiers

PMID: 40051633
DOI: 10.3389/fimmu.2025.1475480
PMCID: PMC11883828

Genes

CD14
ALCAM
CD52
CD63
CXCL12
SDC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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