Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behçet's disease.

doi:10.1016/j.ard.2026.06.033

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Article

Single-cell analysis identifies monocyte signatures of disease activity and clinical subtypes in Behçet's disease.

Annals of the rheumatic diseases - 1 Sept 2026

Carmona Elio, Deniz Rabia, Bes Cemal, Direskeneli Haner, Gül Ahmet, Sawalha Amr H

Abstract excerpt

OBJECTIVES: Behçet's disease (BD) is a multisystem inflammatory disorder with diverse phenotypes and incompletely defined immune mechanisms. This study aimed to map immune dysregulation in BD at high resolution, comparing active vs remission states and identifying pathways linked to clinical phenotypes. METHODS: We performed single-cell RNA sequencing on 247,028 peripheral blood mononuclear cells from 34 patients...

Read the complete abstract on PubMed

Topics

Humans
Behcet Syndrome
Monocytes
Female
Male
Adult
Single-Cell Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Expression Profiling

Middle Aged

Case-Control Studies

Single-Cell Gene Expression Analysis

Interferon-gamma

Phenotype

Transcriptome

Source

Open in PubMed

Identifiers

PMID: 42471274
DOI: 10.1016/j.ard.2026.06.033

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