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Article

A Mouse Model of Partial Pancreas Agenesis Induced by Polo-like kinase 1 Mutation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 Aug 2025

Chen Xiyue, Jia Zhihao, Kuang Shihuan

Abstract excerpt

The pancreas regulates metabolic homeostasis through exocrine and endocrine pathways. Dysfunction or loss of pancreatic β-cells causes diabetes. Here we explore the role of Polo-like kinase 1 (PLK1) in the pancreas using a pancreatic-lineage specific knockout (Plk1PKO) mouse model. Plk1PKO leads to partial pancreatic agenesis, diminishing pancreatic mass. Adult Plk1PKO mice exhibit diabetic syndromes including...

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Source

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Identifiers

PMID: 40879084
DOI: 10.1096/fj.202501377R
PMCID: PMC12345124

Genes

PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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