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Article

The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.

Diabetologia - 1 Dec 2012

Pardo F N, Altirriba J, Pradas-Juni M, García A, Ahlgren U, Barberà A, Slebe J C, Yáñez A J, Gomis R, Gasa R

Abstract excerpt

AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and therefore may be involved in regulation of beta cell homeostasis. The aim of this study was to investigate the...

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PMID: 22926403
DOI: 10.1007/s00125-012-2696-9

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