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Article

Twist1 promoting neointima hyperplasia after vascular injury in diabetes via regulating hyperglycemia-induced phenotype switching of vascular smooth muscle cells.

Atherosclerosis - 1 Oct 2025

Wang Yaoling, Yang Kang, Jiang Gege, Zheng Xichuan, Cheng Fang, Li Wei

Abstract excerpt

BACKGROUND AND AIMS: Neointimal hyperplasia is a key pathology in Type 2 Diabetes Mellitus (T2DM) vascular complications. It involves phenotypic switching of vascular smooth muscle cells (VSMCs) triggered by hyperglycemia, though the exact mechanisms remain unclear. METHODS: We employed Twist1 vascular smooth muscle-specific knockout mice with carotid artery ligation in a T2DM model to study Twist1's role in...

Read the complete abstract on PubMed

Topics

Animals
Twist-Related Protein 1
Neointima
Muscle, Smooth, Vascular
Hyperplasia
Nuclear Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice, Knockout

Phenotype

Cell Proliferation

Myocytes, Smooth Muscle

Male

Hyperglycemia

Signal Transduction

Diabetes Mellitus, Type 2

Cell Movement

Carotid Artery Injuries

NF-kappa B

Protein Kinase C beta

Source

Identifiers

PMID: 40876177
DOI: 10.1016/j.atherosclerosis.2025.120496

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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