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T cell receptor repertoire in cell-free DNA as a proxy for tumor infiltrates in patients treated with pembrolizumab

27 Aug 2025

Abstract excerpt

Profiling tumor and systemic T cell receptor (TCR) repertoires can identify features associated with the clinical benefit of patients with cancer on immune checkpoint blockade therapy. This study reports on the diversity and specificity analysis of TCR sequences from 58 tumor, 306 peripheral blood mononuclear cell (PBMC), and 73 cell-free DNA (cfDNA) samples from 81 patients with solid tumors treated with...

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PMID: 40875293
DOI: 10.1016/j.celrep.2025.116190

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