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Article

Spatially resolved T cell receptor diversity mapping uncovers variability of the cancer immune microenvironment.

EBioMedicine - 1 May 2026

Magoulopoulou Anastasia, Chatzinikolaou Maria, Metousis Andreas, Hu Taobo, Yu Hui, Zerdes Ioannis, Wang Kang, Foukakis Theodoros, Long Mengping, Leandersson Karin, Micke Patrick, Strell Carina, Nilsson Mats

Abstract excerpt

BACKGROUND: T cell receptor (TCR) binding properties have been related to a wide range of pathological conditions, including infections, autoimmunity and cancer. Characterising the TCR repertoire is of great biomedical interest but it has been challenging due to its high structural diversity. METHODS: In situ sequencing (ISS) is a suitable technique for spatial cell typing and linking gene patterns directly to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42034048
DOI: 10.1016/j.ebiom.2026.106264
PMCID: PMC13127328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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