Article

From Plants to Patients: Mitochondrial Stress Signaling as a Systems Framework for Human Disease Vulnerability

2026-08-21

Abstract excerpt

Mitochondria integrate bioenergetic metabolism, redox control, genome maintenance, and stress signaling across all eukaryotes. Although plant and human mitochondria diverged substantially during evolution, both systems retain systems-level principles for sensing mitochondrial dysfunction and communicating stress signals to the nucleus. Here, we develop an integrative comparative in silico framework to evaluate whe...

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Literature Corpus work: fafc47c4-274e-5fa9-a086-607231c1f255
DOI: 10.64898/2026.08.17.745221

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