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Article

Microenvironment-derived factors driving metastatic plasticity in melanoma.

Nature communications - 9 Feb 2017

Kim Isabella S, Heilmann Silja, Kansler Emily R, Zhang Yan, Zimmer Milena, Ratnakumar Kajan, Bowman Robert L, Simon-Vermot Theresa, Fennell Myles, Garippa Ralph, Lu Liang, Lee William, Hollmann Travis, Xavier Joao B, White Richard M

Abstract excerpt

Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum, and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is linked to phenotype switching, where the microenvironment induces switches between invasive/MITFLO versus proliferative/MITFHI states. Since MITF also induces pigmentation, we hypothesize that macrometastatic success should be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28181494
DOI: 10.1038/ncomms14343
PMCID: PMC5309794

Genes

EDN3
ECE2
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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