Article
A Polygenic Risk Score to Predict Incident Heart Failure Across the Spectrum of Cardiovascular Risk.
Journal of the American College of Cardiology - 23 Sept 2025
Haller Paul M, Melloni Giorgio E M, Berg David D, Kamanu Frederick K, Lai Yi-Pin, Antman Elliott M, Bhatt Deepak L, Bonaca Marc P, Cannon Christopher P, Giugliano Robert P, O'Donoghue Michelle L, Scirica Benjamin M, Wiviott Stephen D, Chasman Daniel, Everett Brendan M, Braunwald Eugene, Morrow David A, Ridker Paul M, Ellinor Patrick T, Sabatine Marc S, Ruff Christian T, Marston Nicholas A
Abstract excerpt
BACKGROUND: The clinical utility of a heart failure (HF) polygenic risk score (PRS) is uncertain. OBJECTIVES: The purpose of this study was to investigate the ability of an HF PRS to predict new-onset HF in individuals across the spectrum of cardiovascular risk. METHODS: An HF PRS (>1 million single nucleotide variations) was used to stratify individuals from 7 clinical studies to low (quintile [Q] 1),...
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